You create a macro in the IHML panel and give it the name of the subzone where you are, for example: "Winter's Breath Lake" for the quest The Edge of Winter. Then you just check the item id of the quest item and you can use #showtooltip like below to see that it works. As soon as you zone in the icon from IHML swaps in your macro. That way you can manage most of your daily quests with a single button or keybind.
/targetexact Maiden of Winter's Breath Lake